Hyaluronic Acid
Hyaluronic acid, is a polysaccharide, that occurs naturally in the epithelium of the vagina and other tissues and it is considered a natural reservoir of water in the body. In case of a decrease or loss of hyaluronic acid, the moisture levels stored in the cells will decrease and symptoms of dryness will appear. Therefore, hyaluronic acid is the best material for its natural water retention properties and also participates in the tissue repair process. Hyaluronic acid can be used as an adjunct to the repair of atrophic and dystrophic conditions of the vagina and senile dryness due to estrogen deficiency.
Conventional treatment for postmenopausal syndrome, in terms of systemic and genital symptoms, is based on hormone replacement therapy (TSH). The limitations of this approach are represented by the need to stop treatment after a while and the contraindications for some women. Topical application of hyaluronic acid to control the symptoms of vulvovaginal atrophy in postmenopausal women has been shown to be significantly effective in terms of both objective and subjective improvement.
HA, in treating the symptoms of vaginal atrophy, either has no side effects or has been associated with fewer side effects than vaginal estrogen.
The high molecular weight hyaluronic acid in Halova ovules acts as a protective macromolecule for the vaginal mucosa and the physicochemical properties contribute to passive structural effects, demonstrating hygroscopicity and viscoelasticity and improving hydration, water balance, and structural integrity.
The physicochemical properties of high molecular weight HA contribute to passive structural effects, demonstrating hygroscopicity and viscoelasticity and improving hydration, water balance, and structural integrity. Hyaluronic acid’s anionic properties cause it to attract water and induce swelling, increasing tissue volume and skin structural integrity.
Hyaluronic acid is contained in the medical device Halova in the amount of 5mg / ovule, used to promote hydration of dry vaginal mucosa and reepithelialization of damaged tissue, especially in women for whom hormonal treatment is not indicated. The mechanism of action of hyaluronic acid with a high molecular mass at the level of the vaginal mucosa is realized by the formation of an extracellular matrix with water trapped in the structure. This mechanism does not involve pharmacological, metabolic or immunological action.
